Integrity Research (formerly Perception Labs) – MK-777 (Acetamoren)

Research Compound • Ghrelin Receptor (GHSR1a) Pathway • Ibutamoren (MK-677) Analog • Not for Human Consumption

Overview

MK-777 (Acetamoren) is described by vendors as a next-generation small-molecule ghrelin receptor (GHSR1a) agonist and close analog of Ibutamoren (MK-677). Public, peer-reviewed data on MK-777 are currently limited, and most claims originate from supplier documentation. These should therefore be treated as vendor-reported until validated by independent research.

MK-677, the established comparator compound, is supported by multiple human and animal studies showing stimulation of the GH/IGF-1 axis, improved body composition, and enhanced sleep architecture. MK-777 is positioned as a structural analog built to refine receptor selectivity and pharmacokinetics for preclinical exploration.

Known vs. Unknown

Mechanistic Context (GHSR Axis)

The GHSR1a receptor mediates growth hormone pulsatility, appetite, glucose metabolism, and sleep regulation. GHSR agonists like MK-677 (peer-reviewed) have shown increases in GH and IGF-1 alongside improved sleep structure. MK-777, as reported by suppliers, aims to engage the same receptor family while minimizing appetite and enhancing bioavailability.

Peer-Reviewed Context: GHSR agonists in clinical or preclinical use (e.g., MK-677, macimorelin) demonstrate the physiological importance of ghrelin pathways in metabolic and endocrine research. However, MK-777 itself currently lacks peer-reviewed pharmacodynamic data and should be classified as an exploratory analog.

Specifications (Research Material)

• Brand: Perception Labs
• Compound: MK-777 (Acetamoren)
• Format: Capsules (10 mg each)
• Count: 90 capsules per bottle
• Purity: ≥ 98% (HPLC verified)
• Storage: Store cool, dry, and dark (15–25 °C)
• Quality Control: Heavy metals < 10 ppm; microbial limits compliant with USP
• Intended Use: In-vitro, analytical, or preclinical research. Not for human or veterinary use.

Potential Research Applications (Non-Clinical)

• Receptor Pharmacology: Characterization of binding to GHSR1a and feedback interaction with somatostatin pathways.
• Signal Transduction: GH/IGF-1 axis studies based on analog modeling from MK-677 data (Peer-Reviewed).
• Neuroendocrine Studies: Investigation of ghrelin pathway impact on sleep, stress, and metabolism (Peer-Reviewed context).
• Comparative Analog Testing: Reference benchmarking versus MK-677 or macimorelin (Regulatory anchor compound).

MK-777 vs MK-677 (Ibutamoren)

Peer-Reviewed for MK-677: Demonstrated GH/IGF-1 increase, improved nitrogen retention, and altered sleep architecture in elderly and healthy volunteers.

Vendor-Reported for MK-777: Higher receptor affinity, improved stability, reduced appetite, and sustained IGF-1 elevation (unverified pending publication).

Research Insight: For laboratories studying GHSR analogs, MK-777 may represent an exploratory scaffold to evaluate receptor modulation compared to MK-677, but it should not be assumed equivalent until independent studies confirm pharmacology.

Quality & Transparency

• Each batch tested for identity (HPLC/LC-MS) and purity.
• COA available upon request.
• Lot tracking and tamper-evident seal for laboratory integrity.

Related Educational Articles

• What Is MK-777 (Acetamoren)?
• What Is MK-677 (Ibutamoren)?
• MK-777 vs MK-677: Comprehensive Comparison

FAQ (Research Use)

Is MK-777 identical to MK-677?
No. MK-677 (Ibutamoren) is a documented GHSR agonist with human and animal data; MK-777 is a newer analog with unverified claims awaiting publication.

Is MK-777 an agonist or antagonist?
Most suppliers label it as an agonist, though one lists it as an antagonist — this conflict reinforces the need for independent verification.

Can MK-777 be used in humans?
Absolutely not. It is sold solely for laboratory research and analytical reference — not for human or veterinary use.

What distinguishes ghrelin receptor research?
GHSR studies illuminate the relationship between metabolism, growth hormone release, appetite control, and circadian rhythm, making analogs like MK-777 valuable in preclinical modeling.

How should research compounds be handled?
Follow institutional SOPs for labeling, containment, and disposal. Wear PPE and prevent exposure through ingestion, inhalation, or contact.

Local Availability

📍 Available at Animal Supps in Vineland, NJ. Located in Animal Paradise Gyms at the Cumberland Mall, serving South Jersey and the greater Philadelphia area.

LEGAL / SAFETY DISCLAIMER (Research-Use Only): MK-777 (Acetamoren) is provided exclusively for laboratory research. It is not a dietary supplement, drug, or cosmetic. Not intended for human or veterinary consumption. No medical or performance claims are made. Researchers must comply with all applicable regulations.